Western Medicine CIMETIDINE Tablets B.P. 400mg. (20TABLETS , Aluminum , A white
round tablets )
DESCRIPTION: Cimetidine is
as a HistamineH2-receptor antagomist.
Each uncoated tablet contains:Cimetidine B.P. 200/400mg.
CLINICAL PHARMACOLOGY:Targment competitively inhibits the active
histamine at The H2receptor.
1. Acid Secretion: Noctumal Cimetidine 200/400mg. at bed time
reduces mean hourly H+activity by greater than 85% over an eight
hour period in duodenal ulcer patients, With no effect on daytime
2. Pepsin:Oral Cimetidine 200/400mg reduces total pepsin output as
a result of the Decrease in volume of gastricjuice.
3. Intrinsic Factor: Intrinsic factor secretion was studied with
betazole as a stimulant. Oral Cimetidine 200/400mg.inhibits the
rise in intrinsic factor concentration produced By betazole but
some intrinsic factor was secreted at all times.
Cimetidine is rapidly absorbed after oral administration and peak
levels occur in 45-90 minutes. The half life is approximately
2hours. The principal route of excretion is throughurin.Following a
single oral dose 48% of the drug is recovered from the urine after
24 hours as the parent compound.
INDICATIONS:Treatment and maintenance therapy of active duodenal
ulcer.Treatment of benign gastic ulcers.Treatment of reflux
oesophagitis.Treatment of pathological hyper secreory
PRECAUTIONS:Before giving cimetidine to patients with glastic ulcers the
possibility of malignancy should be considered sine cimetidine may
mask symptoms and dely diagnois. It should be givenin reduced
dosage to patients with imparired renll function.Intravenous
injection of cimetidine should be given slowly and intravenous
infusion is recommended in patients with cardiovascular impairment.
Dosage:Cimetidine should be administered preferably after meals or at
Doses should be adjusted to individual patients need & should
continue as long as clinically indicated.
Active duodenal ulcer:200/400mg thrice daily for 4-5 weeks.
Maintenance therapy for duodenal ulcer:400mg once or twice daily
foe 6 months
Active duodenal ulcer:200/400ma four times a day.
Reflux oesophagitis:400mg t.i.d.for 4-8 weeks.
Pathological hypersecretory conditions(such as Zollinger Ellison
200/400mg four times a day or as diected by the physician.
USES AND ADMINISTRATION:Cimetidine is a histamine H2-receptor antagonist.
Accordingly,it inhibits gastic acid secretion and reduces pepsin
out put; it has also been shown to inhibit other actions of
histamine mediated by H2-receptors. It is used in conditions where
inhibitions of gsatic acid secretion amy be beneficial.Such
conditions include peptic ulcer disease,gastrooesophageal reflux
disease,selected cases of persistent dyspepsia,pathological
hypersecretor stares such as the Zollinger-Ellison syndrome,stress
ulceration,and in patients at risk of acid aspiration during
general anaesthesia.Cimetidine may also be used to reduce
malabsorption and fluid loss in patients with the short bowel
syndrome and to reduce the degradation of enzme supplements given
to patients with pancreatic insullciency.
ADVERSE EFFECTS:Adverse reactions to cimetidine are generally infrequent and are
usually reversible foolwing a reduction of dosage or withdrawal of
therapy.The commonest side-effects reported have been altered bowel
habit,dizziness,tiredness,headache and rashes.
Reversible confusional state,especially in the elderly or in
seriously ill patients such as those with renal failure, have
occasionally occurred. Cimetidine has a week antiandrogenic iffect
and gynaecomastia and impotence have also occasionally occurred un
men receiving relatively high doses for conditions such as the
Other adverse effects which have been reported rarely are
hypersensitivity reactions and fever,arthralgia and myalgia,blood
disorders including agranlocytosis and
thrombocytopenia,interstitial nephritis,hepatotoxicity and
cardiovascular disorders including bardycardia and heart block.
DRUG INTERACTIONS:Cimetidine may inhibit the hepatic metabolism of may drugs by
binding to Cytochrome Althougt may such interactions have been
demonstrated,a few are considered clinically significant,notably
those with phenytoin,hteopylline,lignocanie and other
antiarrhythmica and oral anticoagulants.Reduction in the dosage of
some drugs may be required.
OVERDOSAGE:Overdosage with cimetidine 5.2 ti 20gm including one patient who
tookabout 12g daily for 5 days, has not produced serious toxic
effects,despite plasma concentration of up to 57ug.per mL(peak
concentraction after a 200mg dose is reported to be 1ug per mL.)
However, an overdose of about 12g produced high pulse rate,dilated
pupils,speech disturbances,agitation and disorientation in one
patients and respiratory depression in another patient who had
chronic shizophremia and was also taking trifluoperazine and
hydroxyzine. Also,fatal bradycardia has been reported after
overdosage with an unknown amount of cimetidine an diazepam.
20 tablets/box 1000boxes/carton
Store in a cool,dry & dark place.
Keep away from children.