Western Medicine Piroxicam Injection 20mg/1ml (Has analgesic,
anti-inflammatory and antipyretic effect )
Each ampoule (1ml) contains:
This product is the main component and its chemical name: This
product is mainly composed of piroxicam pivalate, its chemical name
is 2,2-Dimethylpropionic acid 2-methyl-3-[N- (2-pyridyl)
carbamoyl]-2H-1,2-benzothiazin-4-yl ester S, S-dioxide.
Molecular formula: C20H21N3O5S
molecular weight: 415.47
[Properties] this product is yellowish green transparent liquid.
For non steroidal anti-inflammatory drugs, has analgesic,
anti-inflammatory and antipyretic effect. This product can play a
pharmacological role by inhibiting the synthesis of prostaglandin
and inhibiting the chemotaxis of leukocyte and the release of
lysosomal enzymes. The curative effect in the treatment of
arthritis, detumescence and analgesia of indomethacin and aspirin,
Acute toxicity test results: the mouse oral LD50 was 360mg/kg.
The plasma protein binding rate was above 90%. Hepatic metabolism.
The average T1/2 was 50 hours (from 30 to 86 hours), and T1/2 was
prolonged in patients with renal insufficiency. Because of the
longer half-life, a drug can maintain the blood concentration of 24
hours is relatively stable, easy accumulation of multiple dosing.
66% from the kidney excretion, 33% from feces excretion, there are
<5% as the prototype
Indications for symptomatic relief of pain and swelling in various
types of arthritis and soft tissue lesions.
[Usage] intramuscular injection adult 10 ~ 20mg, a day 1 times.
(1) nausea, stomach pain, indigestion and indigestion and other
gastrointestinal adverse reactions are most common.
(2) neutrophils, eosinophilia, increased blood urea nitrogen,
dizziness, dizziness, tinnitus, headache, general weakness, edema,
rash or itching, etc...
(3) abnormal liver function, thrombocytopenia, sweating, skin
ecchymosis, skin peeling, redness, pleomorphic toxic epidermal
necrosis and bullous erythema multiforme (Stevens-Johnson
syndrome), skin allergic reaction to light, blurred vision, eye
irritation, hypertension, hematuria, low blood glucose, depression,
insomnia and mental stress.
[Taboo] contraindications are allergic to this product, peptic ulcer,
chronic gastritis patients disabled.
(1) the long-term application should pay attention to check the
blood and liver and kidney function.
(2) cross allergy. Allergic to aspirin or other nonsteroidal
anti-inflammatory drugs may also be allergic to this product.
(3) during the course of medication such as allergic reactions,
blood abnormalities , blurred vision, mental symptoms, water
retention and severe gastrointestinal reactions, should stop drug.
(4) the following conditions should be used with caution: 1. Blood
coagulation or platelet dysfunction; asthmatic; the cardiac
insufficiency or hypertension; kidney failure; the elderly.
(5) can inhibit platelet aggregation, the role of aspirin is weak,
but sustainable until after stopping for 2 weeks. Preoperative and
postoperative should be discontinued.
(6) this product is symptomatic treatment, must also be the cause
[Pregnant women and lactating women]
(1) in the first 3 months of pregnancy after the use of the drug
can inhibit the delivery of pregnant women, causing dystocia,
gastrointestinal toxicity can occur simultaneously. In addition,
the long-term use of drugs in the late pregnancy may lead to early
atresia or stenosis of fetal ductus arteriosus, resulting in
persistent pulmonary hypertension and heart failure in neonates.
Pregnant women disabled.
(2) this product may cause a decrease in milk secretion, which is
related to the dosage.
[Children medication] Disabled.
[Medication in elderly patients] Catuion.
(1) when drinking alcohol or other anti-inflammatory drugs,
gastrointestinal adverse reactions increased
(2) with the use of anticoagulant drugs such as coumarin, the
latter effect is enhanced, the bleeding tendency is obvious, and
the dosage should be adjusted.
(3) when used in combination with aspirin, the plasma concentration
of the drug can be reduced to about 80% of the total concentration,
while the risk of gastrointestinal ulceration and bleeding tendency
[Packing] 10amps / box, 400 boxes / carton
Store in a cool & dry palce.
Protect from the light.
Keep out of the reach of children.
|Characteristics||Yellowish green transparent liquid||Conforms|
|Identification||Should pass for the prescribed test||Positive|
|Loading capacity||Meet the requirement||Conforms|
Single impurity peak area≤0.5%sum of the peak area of each impurity≤1.0%
≥10μm ≤6000grains/ml≥25μm ≤600grains/ml
|Visible particles||Meet the requirement||Conforms|
|Sterility||Meet the requirement||Conforms|
Contains Piroxicam (C15H13N3O4S)Should be 93.0%~107.0% of the stated amount
Conclusion: The product complies with the requirements of In-house